
The Joe Rogan Experience #2376 - Brigham Buhler
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Sep 9, 2025 Brigham Buhler, founder of Ways2Well, dives deep into the world of functional and regenerative medicine. He discusses the alarming profit motives of pharmaceutical companies and the need for transparency in healthcare. The conversation also covers the controversial role of peptides versus traditional medicine, the challenges posed by FDA regulations, and the growing interest in psychedelic treatments for mental health. Buhler’s insights into preventative care and patient empowerment add a refreshing perspective to the ongoing healthcare debate.
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A Decade Of Compounded Thyroid Success
- Buhler described shipping 6,000 bottles of compounded thyroid medication daily with minimal side effects over a decade.
- He used that scale to argue compounding can be safe, local, and affordable versus retail biologics.
Regulatory Costs Lock Out Small Innovators
- The FDA approval cost model and FDA-fee funding create barriers that favor large pharma and stifle startups.
- Buhler and Rogan argue the $2B approval model functionally forces buyouts and reduces innovation.
Choose Exercise Before Antidepressants
- Prioritize exercise and nonpharmacologic therapies for depression; they often outperform antidepressants.
- Rogan notes exercise and red light therapy can show larger effects than SSRIs in studies.





