Maryland CC Project Hardy: HSCT for the intensivist: indications, interventions, & complications
Jan 8, 2017
Join Nancy Maureen Hardy, an Associate Professor of Medicine and director at the University of Maryland Cancer Center, as she delves into the critical world of stem cell transplantation. She discusses the differences between autologous and allogeneic transplants and underscores the importance of personalized care. Hardy also examines the complexities of cell recovery, potential donor complications like splenic rupture, and the recent advancements in haploidentical transplants that enhance patient outcomes. A blend of science and real-life insights!
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Fatal Apheresis In Cardiac Amyloid Patient
- Nancy shared a fatal collection in a patient with cardiac amyloid who couldn't tolerate volume shifts and died despite resuscitation.
- She now treats even small blood-pressure drops during collection with caution for occult amyloid risk.
Aplasia Is Expected And Manageable
- High-dose chemo intentionally causes aplasia requiring transfusion support and careful management of bleeding and infections.
- Organ toxicities (renal, lung) are common but often partially reversible over months.
Prepare For DMSO Infusion Reactions
- Pre-medicate and monitor for DMSO infusion reactions like flushing, tachycardia, dysphoria, and rare anaphylaxis.
- Keep emergency drugs ready because infusion-related deaths are rare but possible.