Featuring perspectives from Drs Andrew J Armstrong and Rana R McKay, including the following topics:
- Introduction (0:00)
- Intensification of endocrine therapy: Emerging role in nonmetastatic disease; choice of androgen deprivation therapy (3:31)
- Management of castration-resistant M0 disease; PROTACs, CDK4/6 inhibitors and other new endocrine approaches (16:18)
- Hormone-sensitive metastatic disease — Choice of antiandrogen (26:48)
- Castration-resistant metastatic disease (37:06)
- Genomic evaluation; PARP inhibitors for metastatic disease (46:24)
- Ideal sequencing of PARP inhibitors; management of associated side effects (55:21)
- Biomarker testing; MSI-high disease; TKIs with immunotherapy; bispecific antibodies? (59:42)
CME information and select publications