Talking Sleep

Sleep Age with Dr. Mignot

Jan 13, 2023
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ANECDOTE

How Watson The Narcoleptic Dog Joined Mignot

  • Mignot adopted a returned narcoleptic dog named Watson after rescuing him from a breeder in Vermont.
  • Watson works in clinic visits, delights children, and exhibits typical canine cataplexy and sleepiness during long clinic days.
INSIGHT

Sleep Fragmentation Drives Older Sleep Age

  • Sleep fragmentation emerged as the strongest correlate of sleep age rather than only apnea event count.
  • This suggests arousals and disrupted continuity may drive EEG changes linked to mortality more than raw AHI.
ADVICE

Assemble Massive Diverse PSG Datasets

  • Build very large, diverse PSG datasets to make EEG-based predictors generalizable and discover disease-specific EEG fingerprints.
  • Mignot plans to aggregate ~250,000 sleep studies across centers including Stanford, Kaiser, Emory and international sites.
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