Docs Who Lift NAD and NMN with Dr. Charles Brenner
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Feb 12, 2025 
Dr. Charles Brenner, an expert on NAD metabolism and longevity supplements, joins the conversation to break down the science behind NAD and NMN. He explains how NAD coenzymes are crucial for energy metabolism and discusses their decline with age. The chat dives into the misconceptions surrounding these supplements and critiques popular longevity claims made by figures like Andrew Huberman and Peter Atiyah. Brenner emphasizes the importance of a healthy lifestyle over reliance on unproven treatments, making it clear that foundational health practices are essential.
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Pellagra and Niacin
- Pellagra, caused by niacin deficiency, was prevalent in the early 20th century.
- Poor diets lacking fresh foods, particularly in the southeastern US, led to this disease.
Longevity Misconceptions
- Claims that NR or NMN can stop aging by activating sirtuin genes are false.
- Healthy aging depends on lifestyle factors, not just supplements.
Resveratrol: A Scam
- Resveratrol does not activate SIRT1 and is not orally bioavailable.
- The French paradox story connecting resveratrol to longevity is fabricated.