Energized with Dr. Mariza

663: From Wired and Tired to Calm and Energized: The GABA-Mitochondria Connection + How to Fix It at the Cellular Level with Dr. Scott Sherr

Jul 18, 2025
Dr. Scott Sherr, a visionary physician and expert in mitochondrial and nervous system healing, joins to unveil why many women feel both wired and tired. He dives into the crucial role of GABA, a calming neurotransmitter often depleted in midlife, leading to anxiety and insomnia. Delving into mitochondrial dysfunction, he offers practical, science-backed strategies to restore energy and joy naturally. The conversation emphasizes optimizing health through lifestyle changes, improving mental well-being, and reclaiming vitality at any age.
Ask episode
AI Snips
Chapters
Transcript
Episode notes
ANECDOTE

Summer Juggle Anecdote

  • Scott Sherr juggle four kids and a clinical practice during summer camps.
  • Summer brings freedom for kids but creates challenges for parents to find uninterrupted work time.
INSIGHT

Hormones Impact GABA and Nervous System

  • Hormonal shifts in perimenopause cause brain recalibration, reducing stress tolerance and cognitive clarity.
  • Declining progesterone lowers GABA, impairing relaxation and increasing sympathetic nervous system dominance.
INSIGHT

Cortisol’s Role in GABA Deficiency

  • Chronic elevated cortisol depletes GABA, leading to anxiety, insomnia, and depression.
  • Enhancing GABA while improving mitochondrial function is crucial for downstream healing and energy production.
Get the Snipd Podcast app to discover more snips from this episode
Get the app