Bloody Minded Episode 51 - Seeing Red | Approaching Erythrocytosis
Jul 1, 2025
Dive into the world of erythrocytosis, where too many red blood cells can be as problematic as too few! Discover the difference between primary and secondary causes, and hear about unique symptoms like aquagenic pruritus. The discussion includes the role of crucial lab tests and genetic markers, including JAK2 and EPO levels. Real-life case studies illuminate diagnostic challenges. Plus, get insights into the management of conditions like Polycythemia Vera and Budd-Chiari Syndrome, stressing the importance of comprehensive history and testing in treatment!
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Ask About Aquagenic Pruritus
- Ask about aquagenic pruritus by specifically inquiring if itching occurs after a shower or bath.
- This symptom often precedes polycythemia vera diagnosis by up to three years.
Confirm Absolute Erythrocytosis First
- Always confirm if erythrocytosis is absolute by checking hydration status.
- Repeat blood tests if results are unexpected before further workup.
Kidney Response to Hypoxia
- Kidneys respond to hypoxia by increasing erythropoietin production to raise red cell numbers.
- Chronic hypoxia from smoking, lung or heart disease causes secondary erythrocytosis.