Episode 141 - Spyros Papapetropoulos - CEO Phragma Therapeutics

Today’s guest brings one of the broadest and most thoughtful perspectives in neuroscience, spanning clinical practice, drug development, investing, and company building.

Dr. Spyros Papapetropoulos is a neurologist, neuroscientist, and biotech leader who has spent his career at the intersection of science, medicine, and innovation. With deep experience across both large pharma and emerging biotech, he has built a reputation for translating complex neuroscience into clear strategic direction - helping shape how new therapies move from idea to impact.

Over the years, Spyros has worked across multiple dimensions of the CNS ecosystem, from research and development through to leadership, investing, and advising. His work has given him a unique vantage point on what it really takes to build successful neuroscience companies, where the field is heading, and why progress in CNS demands a different kind of thinking.

He is also the author of Mind Odyssey, a book that reflects on neuroscience, innovation, and the future of brain health - themes that closely mirror the work he continues to do across the biotech landscape today.

In this conversation, we explore Spyros’ journey through neuroscience, his view on the current state of the CNS biotech ecosystem, where drug development is heading next, and what it takes to build companies, teams, and ideas that can genuinely move the field forward.