All-In with Chamath, Jason, Sacks & Friedberg Are Psychedelics the Key to Living Forever? (ft. Bryan Johnson)
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Mar 26, 2026 
Bryan Johnson, Braintree founder and Blueprint longevity experimenter, dives into why he tried 5-MeO-DMT and psilocybin. The conversation explores brain scans, default mode network resets, bad-trip and psychosis risks, and how psychedelics could fit into anti-aging research. It also branches into GLP-1s, gene therapy, organoids, and the future of human optimization.
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Bryan Johnson Framed 5 MeO As A Longevity Test
- Bryan Johnson tried 5-MeO-DMT as a longevity experiment after psilocybin data made him think psychedelics might be anti-aging tools.
- He said the onset hit within 10 seconds, forced total surrender, and then opened into unmatched bliss he called his most dynamic human experience.
Psychedelics May Rewire The Brain By Quieting Ego
- Bryan Johnson says psychedelics weaken or annihilate the default mode network, the system behind self, ego, and repetitive rumination.
- He and David Friedberg compare it to scrambling airline routes, creating new connectivity patterns that may drive neuroplasticity and trauma relief.
The Afterglow Felt Like Returning To Childhood
- Bryan Johnson says the aftereffects felt childlike rather than merely pleasant, with less internal chatter and more ease in daily life.
- He described laughing in a dream, feeling spontaneous excitement, and handling conflict with Kate without defensiveness or scorekeeping.