The Optispan Podcast with Matt Kaeberlein 6 Months on TRT Changed My Body (THIS Is My Takeaway)
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Dec 13, 2025 In this engaging discussion, Matt shares his transformative experience on TRT, revealing weight gains and enhanced physique. He debates the merits of rapamycin versus fasting for longevity and tackles misconceptions about microplastics. Matt’s 4:30 AM wake-up routine enhances his productivity, and he reflects on the benefits of hyperbaric oxygen therapy. He also dives into bloodwork changes he's noted during TRT, including HDL levels. Plus, updates on his upcoming books spark curiosity—packed with practical health insights!
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Match Sleep To Your Chronotype
- Align your sleep schedule with your chronotype rather than forcing a specific wake time.
- Regular routine matters more than an unusually early alarm if sleep quality and HRV are good.
Simple Creatine Routine
- Take five grams of creatine daily as a simple, effective supplement.
- Treat creatine as a tier-one supplement but prioritize foundational lifestyle factors first.
HBOT Works For Hypoxia, Not Proven For Longevity
- Hyperbaric oxygen has clear utility for focal brain hypoxia but weak, inconsistent evidence for broad cognitive or longevity benefits.
- Placebo effects and study design challenges complicate interpretation of HBOT trials.
