Barbell Shrugged How Lifting Weights Affects Your Genetics w/ Dr. Kevin Murach, Anders Varner, and Doug Larson #748
May 22, 2024
Dr. Kevin Murach discusses how weightlifting affects genetics, highlighting gene expression in muscle growth. The podcast delves into the importance of education in training, an athlete summit event, and the speaker's journey in exercise physiology. It also explores muscle recovery, factors influencing muscle growth, genetic influence on weightlifting, manipulation of cells for muscle growth, and post-workout nutrition for protein synthesis.
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Timed Gene Waves Drive Postworkout Adaptation
- Resistance exercise triggers time‑staggered gene expression and epigenetic changes that guide muscle adaptation.
- Kevin Murach profiled biopsies at 0.5, 3, 8 and 24 hours to map which genes and epigenetic marks peak when after a workout.
Epigenetics Determines Which Exercise Genes Activate
- Epigenetics controls which genes muscle cells can access without changing DNA sequence.
- Murach explains that exercise accesses already‑accessible genes to produce proteins (e.g., myosins) via ribosomes.
Omics Pointed To A Potent Master Regulator
- Large omics profiling can highlight candidate master regulators controlling many downstream exercise genes.
- Murach's group used transcriptomics plus epigenetics to narrow the response to a potent gene called Myc (MKI67/MYC family context).