Episode #229: Supportive Oligonucleotide Therapy (SOT) with Dr. Clayton Bell, MD

Why You Should Listen:

In this episode, you will learn about the role of Supportive Oligonucleotide Therapy, or SOT, in the treatment of Lyme disease and vector-borne infections.

About My Guest:

My guest for this episode is Dr. Clayton Bell. Clayton Bell, MD is a leading integrative and functional medicine physician dedicated to helping patients achieve deep, lasting wellness. Dr. Bell works with Lyme and vector-borne infections, integrative cancer support, environmental medicine including mold, mycotoxins, heavy metals, and detoxification; hormones, cardiometabolic and GI health, and mind-body balance. Combining his Western medical training with functional, integrative, environmental, and Ayurvedic approaches, he focuses on uncovering the root causes of health concerns. Patients benefit from personalized, whole-person treatment plans that empower the body's natural healing ability and support sustainable wellness from the inside out. Dr. Bell provides online consultations that offer accessible, holistic care tailored to each individual's needs.

Key Takeaways:

• What place does SOT have in the treatment arsenal for chronic Lyme disease?
• What is AOT or Antisense Oligonucleotide Therapy?
• What testing is acceptable for a practitioner to request an SOT for a patient?
• What testing is offered by Biocentaur?
• How does SOT work in the body?
• How does the practitioner determine which SOT to request when many infections may be positive?
• What SOTs are available for vector-borne infections and viruses?
• What are the foundational steps to prepare a patient for an SOT?
• Do certain therapies need to be stopped before testing and while doing SOT?
• How important is immune modulation or creating immune tolerance to the microbes?
• What is the SOT administration process?
• How are Herxheimer reactions addressed with using SOT?
• Can the SOT push back one infection and then lead to another becoming the dominant focus of the immune system and symptom presentation?
• How long should there be between SOTs? Is there a maximum number of SOTs that can be done?
• Can SOT reach all potential reservoirs of infection in the body?
• What role do biofilms play in the context of SOT?
• Have any specific SOTs been helpful in the contents of EDS, PANS/PANDAS, or Long COVID?
• What role might SOT play in neurodegenerative conditions?
• Can SOT resolve autoimmunity, inflammation, or oxidative stress?
• When SOT does not appear to work, how does the practitioner troubleshoot potential reasons?
• - What is the cost of SOT?

Connect With My Guest:

MetaMedical.life DrClaytonBell.com

Related Resources:

RGCC North America RGCC International RGCC Vector-Borne and Virus SOTs available RGCC Provider Map

Interview Date:

February 24, 2026

Transcript:

To review a transcript of this show, visit https://BetterHealthGuy.com/Episode229.

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Disclaimer:

The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.