How To! with Mike Pesca How To Take Psychedelics for Your Mental Health with Dr. Will Van Derveer
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Mar 17, 2026 
Myq Kaplan, stand-up comedian and philosopher exploring his own anxiety. Dr. Will Van Derveer, veteran psychiatrist and author specializing in psychedelic therapy. They discuss using ketamine, psilocybin, and MDMA to loosen rigid brain patterns. They compare rapid ketamine effects with psilocybin’s promise, weigh risks and preparation, and stress therapy and integration over casual use.
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Myq's Decade Of Ayahuasca Ceremonies
- Myq Kaplan described dozens of ayahuasca ceremonies in Peru and Brooklyn that were therapeutic for him.
- He contrasted guided clinical use with his recreational and ceremonial experiences.
Psychedelics Loosen Rigid Self Identity
- Psychedelic therapy transiently loosens rigid self-identity by disrupting the brain's default mode network.
- Functional MRI shows a physical 'shaking the snow globe' effect that opens new perspectives and psychological flexibility.
Check Legal Status Before You Try Anything
- Know legal status before pursuing a psychedelic: psilocybin is legal only in Oregon and Colorado; ketamine is legal nationwide; MDMA remains illegal.
- Choose treatments available where you live and verify regulatory context.
