Mastering Nutrition A PhD's Secret Weapon: The Four Biomarkers Every Expert Should, But Doesn't, Analyze
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Oct 13, 2023 Discover the importance of neglected biomarkers like glucose and redox status. Learn about interpreting biomarkers for personalized nutrition and diets. Explore the breakdown of glucose and energy extraction from food. Understand release valves and biomarker ratios for catabolic breakdown and respiratory chain functioning. Analyze biomarkers related to metabolism and the impact of biotin supplementation. Emphasize the importance of analyzing nutrient response and energy metabolism. Discuss redox reactions and the NAD+/NADH ratio. Explore normal ranges for ketone and lactate ratios. Discuss biomarkers for diagnosing metabolic enzyme deficiencies. Explore balancing fasting and fed state signaling for mitochondrial biogenesis. Learn about respiratory chain complexes and treatment strategies. Discover biomarkers and tests for nutritional assessment.
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Keto + Thiamine Made A Client Worse
- A client worsened on a ketogenic diet plus high-dose thiamine and became bedridden.
- Measuring lactate and pyruvate beforehand would have prevented the harmful intervention.
How The Two Ratios Map Compartments
- High lactate:pyruvate means cytosolic electron buildup; high BHB:AcAc means mitochondrial electron buildup.
- If both ratios move together malate-aspartate shuttle works; if opposite, the shuttle is failing.
Apply Practical Normal Ranges
- Use the podcast's practical normal ranges when testing after an overnight fast and no alcohol for 48 hours.
- Treat BHB:AcAc <0.3 or >8 and lactate:pyruvate outside ~4–16 as strongly abnormal.