Progress, Potential, and Possibilities Podcast / Show Alzheimer’s Disease Modification vs Prevention - Where the Science Stands - Dr. Kevin Rynearson, Ph.D. - Chief Scientific Officer, Acta Pharmaceuticals / Head of Research, CogniSHIELD Global
Dr. Kevin Rynearson, Ph.D. is a medicinal chemist and translational neuroscientist focused on developing disease-modifying therapies for Alzheimer’s disease.
Over more than a decade, Dr. Rynearson's work has centered on the design and optimization of gamma-secretase modulators, an approach aimed at altering amyloid biology in a safer and more physiologically balanced way than earlier generations of therapies.
During his time at the University of California San Diego School of Medicine, Dr. Rynearson helped advance mechanistic understanding of gamma-secretase activity, tau phosphorylation, and structure-activity relationships guiding next-generation Alzheimer’s drug design.
Dr. Rynearson currently serves as Chief Scientific Officer of Acta Pharmaceuticals ( https://www.linkedin.com/company/acta-pharmaceuticals/ ), where he leads development of a clinical-stage gamma-secretase modulator emerging from decades of collaborative research, including work with renowned Alzheimer’s researcher Rudy Tanzi.
In parallel, Dr. Rynearson is Head of Research at CogniSHIELD Global ( https://cognishield.com/ ), exploring preventative strategies and interventions aimed at supporting brain resilience and healthy cognitive aging.
Dr. Rynearson’s work sits at the intersection of medicinal chemistry, neurobiology, and preventive neurology — with a focus on shifting Alzheimer’s treatment from late-stage symptom management toward early intervention and disease prevention.
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