The Intern At Work: Internal Medicine

200. A Window of Opportunity: Preventing and Treating HIV Opportunistic Infections

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Jun 27, 2023
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ADVICE

Start With ABCs And HIV Context

  • Begin every evaluation with ABCs and vital signs, and call ICU early if the patient is unstable.
  • Review recent CD4 count and viral load to contextualize symptoms and refine your differential diagnosis.
ADVICE

Suspect PCP Below CD4 200

  • In patients with CD4 <200 who have cough or dyspnea, prioritize pneumocystis pneumonia in your differential.
  • Look for indolent nonproductive cough and exertional dyspnea and obtain chest imaging and LDH to guide evaluation.
ADVICE

Think Histoplasmosis With CD4 <150

  • For CD4 <150 and relevant exposures, suspect Histoplasma capsulatum and screen for disseminated disease.
  • Ask about caves, bird or bat droppings, endemic travel, and examine for hepatosplenomegaly, lymphadenopathy, and skin lesions.
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