The Hunter Williams Podcast

Peptides & Longevity Medicine Explained by a Real Cardiologist | Dr. Abid Hussain, MD

Mar 27, 2026
Dr. Abid Hussain, MD — triple board certified cardiologist turned longevity physician at Boulder Longevity Institute. He explains why cholesterol alone misleads and how APOB, particle size, and AI cardiac imaging reveal hidden plaque. He debunks testosterone myths, covers HRT differences, and walks through peptides, mitochondrial peptides, and why SGLT2 inhibitors are an underrated longevity tool.
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ADVICE

Prefer Bioidentical HRT And Start Low In Women

  • For women use bioidentical hormones and avoid oral estradiol if clot risk is a concern; prefer topical estradiol and micronized oral progesterone when possible.
  • Treat women gently and start low, especially if many years postmenopausal, to reduce side effects like breast tenderness or spotting.
ANECDOTE

77 Year Old Patient Started HRT After Reclassification

  • Dr. Abid described a 77‑year patient who agreed to start HRT after FDA reclassification and education.
  • He emphasized there's no age cutoff for starting hormones but recommends slow, low initial dosing to avoid side effects.
ADVICE

Start Peptides By Learning A Few Key Agents

  • Learn a small set of well-studied peptides first (BPC-157, TB4, Thymosin alpha-1, CJC, ipamorelin) before exploring the broader list.
  • Focus on cellular mechanisms — endothelial repair, collagen/fibrosis modulation, and nitric oxide effects — to match peptide to clinical goals.
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