Myers Detox Podcast

How Nitric Oxide Deficiency Drives Erectile Dysfunction, High Blood Pressure, and Rapid Aging | Nathan Bryan

Feb 12, 2026
Dr. Nathan Bryan, a nitric oxide researcher and entrepreneur with 25+ years in the field, explains how nitric oxide deficiency fuels high blood pressure, erectile dysfunction, insulin resistance, and accelerated aging. He reveals surprises like mouthwash killing helpful oral bacteria, heavy metals scavenging nitric oxide, and practical fixes including oral lozenges, supporting the oral microbiome, and timing NO with saunas and red light.
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INSIGHT

Nitric Oxide Is A Foundational Molecule

  • Nitric oxide is a foundational signaling gas that dilates blood vessels, mobilizes stem cells, activates telomerase, and boosts mitochondrial energy production.
  • Nathan Bryan says adequate nitric oxide underpins health optimization, longevity, and disease prevention.
INSIGHT

Viagra Needs Nitric Oxide To Work

  • PDE5 inhibitors like Viagra work downstream of nitric oxide by prolonging cyclic GMP, not by creating nitric oxide.
  • Nathan Bryan notes 50% of men don't respond because they lack nitric oxide production for the drug to act on.
ADVICE

Support Microbes That Make Nitric Oxide

  • Support your oral and skin microbiomes because specific bacteria convert dietary nitrate into nitrite and then nitric oxide.
  • Nathan Bryan recommends diet, oral microbiome care, and adequate stomach acid to fuel this pathway.
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