Dwarkesh Podcast Evolution designed us to die fast; we can change that — Jacob Kimmel
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Aug 21, 2025 
In this enlightening conversation, Jacob Kimmel, Co-founder and President of NewLimit, shares his groundbreaking work in reversing aging through epigenetic reprogramming. He discusses why evolution hasn't optimized for longevity and the complexities of drug discovery. The chat delves into the role of transcription factors in rejuvenating cells and innovative gene delivery methods that could transform medical treatments. Kimmel also offers intriguing insights into CAR-T cell therapy and how biotech innovations may revolutionize healthcare.
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Treat Nucleic-Acid Delivery As The Core Problem
- Focus on nucleic-acid delivery as a first-order primitive to drug any gene. Combine vector choice (LNP vs AAV) with sequence engineering to broaden or narrow tissue specificity.
Cells As Future Drug Delivery Platforms
- Engineered cells will likely become the long-term delivery solution, acting as persistent, programmable medicine factories. Cells offer complex logic, longevity, and broad tissue access compared with static vectors.
Local Tissue Repair Yields Systemic Benefits
- Repairing a single tissue often produces systemic benefits because organs send coordinating signals across the body. Transplant and endocrine medicine examples show local rejuvenation yields broad health gains.
