The Proof with Simon Hill Gut microbiome in inflammatory and metabolic diseases | Suzanne Devkota, PhD
TMAO and Heart Disease Nuance
- Microbes produce TMA, converted in the liver to TMAO associated with heart disease.
- It likely acts synergistically with other lifestyle factors rather than being a sole cause.
Microbiome Critical in IBD
- IBD strongly involves genetics and microbiome; germ-free mice do not develop colitis.
- The microbiome is necessary but not solely sufficient to cause IBD.
Food Additives and IBD Link
- Food additives in Western diets may contribute to microbiome changes linked to IBD.
- Specific additives like trehalose can promote harmful bacteria growth increasing IBD risk.
Episode #267. Join me for a deep dive into the influence of the gut microbiome on inflammation and metabolic disease. In this fascinating exchange with Dr Suzanne Devkota, we explore the role of the gut in these conditions, shedding light on food allergies, IBD, and obesity. You’ll learn the practical tips you need to nurture a healthy microbiome, as well as gain a better understanding of what we do – and don’t – know about this incredible system.
Specifically, we discuss:
- Intro (00:00)
- The evolving field of microbiome research (02:13)
- Gut microbe on social media (09:32)
- Microbiome definition (12:48)
- Why the focus on gut bacteria? (13:55)
- Differences in Microbes (16:02)
- Microbial shifts and adaptations (18:45)
- Microbes perturbations (21:35)
- Human microbiome in evolution (23:54)
- Healthy microbiome and diversity (27:47)
- Is the microbiome the sole driver of metabolic diseases? (33:05)
- Dietary patterns and FODMAP intolerance (41:07)
- Saturated fat and gut health (49:15)
- Microbiome metabolites and heart disease risk (57:42)
- Inflammatory bowel disease (IBD) and dysbiosis (1:02:09)
- Food additives (1:12:29)
- Supporting the microbiome in IBD (1:15:29)
- Microbiome's interaction with fat cells (1:16:52)
- Short-chain fatty acids and appetite regulation (1:29:26)
- Practical tips for nourishing a healthy gut (1:31:05)
- Microbiome's interaction with Polyphenols (1:38:43)
- On supplements and fermented foods (1:39:15)
- Factors affecting gut health beyond nutrition (1:46:22)
- Outro (1:50:10)
Connect with Dr Suzanne Devkota on Instagram and Twitter. Learn more about her research at http://www.devkotalab.com/thelab.
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Enjoy, friends.
Simon
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Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
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