The a16z Show Marc Andreessen: Who Runs the World’s AI?
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Feb 10, 2026 
Marc Andreessen, cofounder of Andreessen Horowitz and Mosaic co-creator, discusses AI reversing decades of stagnant productivity. He explores where value will land across models, chips, infrastructure, and apps. He also tackles open source, US‑China competition, infrastructure optimization, and surprising advances like multimodal voice UIs and agents.
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Why Productivity Stalled Since 1971
- Productivity growth has been unusually low since about 1971 despite big tech advances.
- Marc Andreessen argues regulatory choices and priorities outside chips/software largely caused the stagnation.
Design For Regulatory Realities
- Recognize regulation slows AI-driven productivity gains and plan product roadmaps accordingly.
- Balance aggressive product ambition with realistic regulatory constraints to avoid being blocked from real-world use.
Using GPT As An Unlicensed Doctor
- Marc tried GPT while sick and described it as an endlessly patient, knowledgeable doctor.
- He contrasts that experience with current licensing and legal limits on AI practicing medicine.