Perimenopause and the New Midlife Playbook with Dr. Alyssa Dweck (Episode 266)

Mar 18, 2026

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Now that menopause is finally getting the research and medical attention it deserves, we are finally putting perimenopause in the spotlight as a pivotal period in a woman’s life that demands its own care and attention. This week, midlife gynecologist Dr. Alyssa Dweck returns to break down perimenopause care, the state of hormone therapy, and much more. We dig into how perimenopause is so variable, how to think about the pill, IUDs, hormone therapy, and the new non-hormonal drugs, plus what hot flashes may be revealing about your heart health. We wrap with a look at wearables, telehealth, and the coming era of precision menopause medicine that treats ovaries as the powerful “conductor” organ they are. (Note: Dr. Dweck accidentally misspoke regarding fezolinetant. She would like to clarify that it is an NK3 receptor antagonist not an NK1.)

Alyssa Dweck MS MD FACOG MSCP is a practicing gynecologist at Well by Messer in New York City and the Chief Medical Officer at Bonafide Health. Dr. Dweck is a menopause society certified provider with a special interest and expertise in female sexual health and medical sex therapy. Dr. Dweck was recently appointed to the Board of Directors of HERmedicine, a nonprofit education organization dedicated to advancing women’s healthcare across the lifespan. This role at HERmedicine recognizes her as a distinguished leader dedicated to educating clinicians and integrating evidence-backed care into everyday medical practice. Dr. Dweck has authored three books, the most recent The Complete A to Z For Your V also co-hosts Business of the V, a podcast which focuses on unmet needs in gynecology and women’s health and the businesses created to fulfill these needsYou can learn more about her and her work at drdweck.com

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