Rheumnow Podcast Telling You Where to Go (12.19.2025)
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Dec 19, 2025 Discover intriguing connections between Psoriatic Arthritis and Familial Mediterranean Fever. Learn about a groundbreaking GLP-1 trial for knee osteoarthritis that reveals promising results. Uncover how certain lab tests could accurately predict systemic sclerosis-related lung issues. Delve into the importance of skin cancer screenings for immunosuppressed patients. Plus, explore the impact of hydroxychloroquine on ocular toxicity and the yearning for more training among healthcare providers in rheumatology.
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IgA Autoantibodies In Rheumatoid Arthritis
- IgA-RF appears in ~50% of RA patients and IgA-ACPA in 20–40%, with specificity similar to standard tests.
- Jack Cush says IgA autoantibodies may link mucosal immunity to RA and predict worse outcomes and TNF inhibitor nonresponse.
Do Skin Exams For Patients On TNF Inhibitors
- Perform periodic skin exams for patients on TNF inhibitors and consider dermatology referral for those with prior skin cancer.
- Jack Cush reminds clinicians the TNF inhibitor label recommends annual skin checks due to increased non-melanoma and melanoma risk.
RA Is Associated With Higher CKD Risk
- RA patients show higher rates of stage 3+ CKD and albuminuria compared with controls in a large Austrian cohort.
- Jack Cush emphasizes routine lab monitoring already captures creatinine but notes multiple possible etiologies for renal risk.