Witness History

The discovery of nerve growth factor

Feb 9, 2026
Rita Levi-Montalcini, Italian neurologist and Nobel laureate who secretly did wartime bedroom experiments. She recounts how chicken embryo work revealed nerve cell death. She describes follow-up discoveries in the US that pointed to a protein driving nerve growth. The story traces initial skepticism to eventual recognition and lasting scientific legacy.
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ANECDOTE

Bedroom Laboratory Discovery

  • Rita Levi-Montalcini continued her research in a makeshift bedroom lab in Turin when Jews were banned from universities in 1938.
  • She discovered nerve cell death after cutting a limb of a chicken embryo and observing spinal cord cells degenerate.
ANECDOTE

Chicken Embryo Experiment

  • Rita performed an experiment on a chicken embryo and found that cutting a developing limb caused related nerve cells in the spinal cord to die.
  • This provided the first evidence that developing nerve cells depend on peripheral targets for survival.
INSIGHT

External Factors Control Nerve Growth

  • Rita's observations attracted Victor Hamburger, who validated her results and collaborated with her in the US.
  • Together they showed external factors can control nerve growth, changing assumptions about intrinsic-only nerve development.
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