This Week in Cardiology Feb 06 2026 This Week in Cardiology
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Feb 6, 2026 Problems with a common risk score and its impact on young non-Hispanic Black adults. Results from an oral PCSK9 inhibitor trial showing large LDL reductions. A Factor XI inhibitor cutting recurrent ischemic stroke without extra major bleeding. Fresh looks at statin adverse effects and how nocebo and patient preference shape preventive decisions.
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PREVENT Underestimates Risk In Young Black Adults
- The PREVENT risk equations underestimated 10-year cardiovascular risk by about 46% in non-Hispanic Black young adults.
- This underprediction may cause substantial undertreatment of a high-premature-CVD-burden population.
Don't Treat Risk Scores As Absolute Rules
- Use risk scores as one tool, not an absolute rule, when deciding prevention strategies for younger patients.
- Consider individual context and avoid rigid thresholds like a single 7.5% cutoff to guide therapy.
Resist The Urge To Over-Intervene
- Mandrola recalled an EP lab sign: 'resist the urge to help,' highlighting harm from well-intended policies.
- He compared this to cases where policy (like readmission penalties) produced unintended harm.