Flex Diet Podcast Episode 372: PCOS Made Practical, Body Recomp Basics, and the Wild West of Peptides (w/ Dr. Ashley Dwyer)
In this episode of the Flex Diet Podcast, I sit down with Dr. Ashley Dwyer, a PharmD-turned nutrition and fitness coach, to cover a wide range of topics, with a strong focus on PCOS (polycystic ovarian syndrome), a metabolic condition that affects fertility, cycles, and systemic health.
We dig into practical lifestyle strategies for insulin-resistant PCOS, including balanced meals, protein and fiber, blood sugar management, movement, and stress reduction, plus why long-term keto often isn’t a great fit. We also discuss GLP-1 medications, including concerns about HRV and resting heart rate, and why foundations and coaching matter when someone uses them.
Finally, we discuss the current “wild west” of peptides, the lack of human data, dosing and purity issues, and the importance of transparency, consistency, and identity-based behavior change for body composition and long-term health.
Sponsors:
- Flex4: Dr Ashley Dwyer's top 4 things for women to improve body composition: https://miketnelson.com/flex4
- Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8
Check out:
- Real Coaches Summit 2026: https://realcoachessummit.com
Available now:
- Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.
Episode Chapters:
- 05:02 Meet Dr Ashley
- 06:16 PCOS Explained
- 09:37 PCOS Nutrition Basics
- 11:31 Keto And Thyroid
- 15:21 Stress And Cardio
- 18:27 GLP1 Heart Effects
- 22:21 Maintenance And Habits
- 30:27 Identity And Mindset
- 32:56 Identity Reps and Habits
- 33:25 Daily Affirmations and Reminders
- 34:23 Taming Negative Self Talk
- 36:24 Peptides Hype and Risks
- 38:18 Anecdotes Dosing and Quality
- 42:38 Influencers Quick Fixes Foundations
- 43:56 Research Funding and Regulation
- 47:40 Transparency Natty vs Enhanced
- 49:55 Coaching Clients on Supplements
- 56:20 Outro Summit and Disclaimers
Flex Diet Podcasts you may enjoy:
- Episode 359: Debunking Women’s Fitness Myths with Dr. Lauren Colenso-Semple
- Episode 292: Expert Insights on Pelvic Floor Health, Stress Management & Functional Technique with Dr Catrina Fabian
Connect with Dr Dwyer:
- Instagram: https://www.instagram.com/dr.dwyer
Get In Touch with Dr Mike: