How I Built This with Guy Raz Advice Line with Serial Entrepreneur Mark Cuban
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Jan 29, 2026 
Mark Cuban, serial entrepreneur and investor who built tech companies, owns the Dallas Mavericks, and launched Cost Plus Drugs. He weighs in on breaking into big-box retail, marketing when users and buyers differ, rebooting handcrafted products with premium pricing, tackling seasonality and supply-chain choices, and reshoring drug manufacturing using robotics and transparency.
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Make Manufacturing Economical First
- Negotiate regulatory and application costs before scaling manufacturing domestically.
- Use modular, robotics-driven production to pivot quickly between drugs and control margins.
Mission Trumps Pure Profit
- Purpose-driven missions sustain long-term entrepreneurial energy and curiosity.
- Mark Cuban finds mission-level goals more motivating than chase for big financial returns.
Choose Margin Over Rapid Channel Expansion
- Prioritize profitability over chasing top-line sales, especially with distributor and stocking fees.
- If retail margins don't work, double down on e-commerce and shift those funds into marketing.