Short Wave Why Is The Coronavirus So Good At Spreading?
Mar 24, 2020
Ed Yong, a science reporter for The Atlantic, discusses the fascinating spread of the coronavirus, highlighting its unique spike protein and the crucial role of the furin enzyme in infection. He shares insights on how the virus adapts and contrasts its transmission with earlier strains, including SARS. The conversation also touches on how seasonal changes impact its spread, likening the pandemic to a relentless wildfire. Yong's expertise sheds light on the challenges of pandemic preparedness and the intricate world of coronavirus research.
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Sticky Virus
- This novel coronavirus's spike protein binds more tightly to ACE2 receptors than SARS-classic.
- This stronger bond means less virus is needed for infection, increasing transmissibility.
Spike Activation
- The coronavirus spike protein is activated by being split, similar to an avocado.
- The enzyme furin, found throughout the human body, facilitates this split, potentially explaining the virus's wide spread.
Dual Infection Sites
- The virus infects both upper and lower airways.
- Upper airway infection causes mild symptoms and easy spread, while lower airway infection leads to severe illness.