NEI Podcast E273 - Busting Myths About Antidepressants with Dr. Jeffrey Strawn
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Jan 14, 2026 Join Dr. Jeffrey Strawn, a leading expert in psychiatry and pharmacology, as he busts common myths surrounding antidepressants. He and Dr. Andy Cutler delve into the efficacy of these medications compared to placebos and clarify the risk of suicidality. They discuss when to initiate treatment, the importance of balancing medication with therapy, and how to effectively communicate side effects to patients. Strawn also tackles the misconception of antidepressants altering personality, emphasizing their role in symptom relief. A must-listen for anyone curious about mental health treatment!
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Boxed Warning Had Unintended Harms
- The FDA boxed warning on antidepressants (2004) led to reduced prescribing and unintended harms, including rises in youth suicide rates and decreased diagnosis.
- Observational data show suicidality often rises before starting antidepressants and declines after treatment begins.
Monitor Closely And Screen For Bipolar
- Prioritize vigilance and timely treatment over fear when considering SSRIs for youth; monitor closely after starting medication.
- Screen depressed patients for bipolar disorder before prescribing unopposed antidepressants.
Measurement Hides Drug Effects
- Antidepressants often help anxiety and OCD as much as or more than depression, but high placebo response and measurement limits can obscure drug effects.
- Trial instruments often miss functional outcomes like avoidance, reducing observable drug-placebo differences.