Sam Miller Science S 873: A1C Explained: When This Popular Marker Helps, and When It Misleads
A1C is one of the most commonly used markers for assessing metabolic health, but it’s also one of the most misunderstood. In this episode, I revisit the “Overrated or Underrated” framework to break down what A1C actually measures, where it can be useful, and why it often fails to tell the full story. We explore the many conditions, supplements, medications, and physiological states that can falsely elevate or suppress A1C, leading to flawed conclusions about insulin sensitivity. Topics discussed:
- What A1C measures
- Overrated versus underrated markers
- False A1C elevations
- False A1C reductions
- Anemia and A1C
- Protein intake effects
- Medications and A1C
- Endurance training considerations
- Ethnicity and lab interpretation
- Better insulin sensitivity markers
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