Blood Bank Guy Essentials Podcast

087CE: Transfusion-transmitted Infections with Suchi Pandey

Dec 16, 2020
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ANECDOTE

HIV Crisis Reshaped Blood Safety

  • The HIV epidemic in the 1980s tragically drove major changes in transfusion safety and testing.
  • The first licensed anti-HIV test in 1985 sharply reduced transfusion-transmitted AIDS cases.
ADVICE

Combine Deferral And Testing For HIV

  • Use donor questionnaires plus NAT and antibody testing for HIV to minimize risk.
  • Apply deferrals aligned to window periods; FDA moved behavioral deferral from one year to three months.
INSIGHT

HTLV Screening Despite Low Risk

  • HTLV types 1 and 2 are rare transfusion risks but still screened by antibody testing.
  • HTLV window period is long (~51 days) but residual transfusion risk is extremely low (~1 in 3 million).
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