Liver Health Optimization in Clinical Practice with Dose | Kiran Krishnan, PhD

In this episode of the Innovations and Clinical Implementation podcast recorded at LongevityFest 2025, hosts Dr. Lexi Gonzales and Jessica Carter discuss functional liver health with Dr. Kiran Krishnan—a research microbiologist and globally recognized expert on the human microbiome and co-founded Microbiome Labs. Dr. Krishnan argues that standard enzymes like AST and ALT are late-stage markers of damage, and instead advocates for proactive support using Dose, a clinically validated liquid therapeutic that serves as a foundational tool for metabolic health and reduces pill burden. The conversation explores the vicious cycle between liver dysfunction and dysbiosis—where "leaky gut" increases endotoxin load (measurable via LBP and HDL3) and reduced bile flow drives SIBO—and explains that Dose is uniquely formulated without black pepper to ensure curcuminoids are metabolized locally by the liver for repair rather than being shunted into systemic circulation.

For access to episode resources, click HERE.