The Stem Cell Podcast Ep. 53: Automated iPS Cells Featuring Dr. Scott Noggle
Sep 15, 2015
Dr. Scott Noggle is the Vice President for Stem Cell Research at the New York Stem Cell Foundation, pioneering automated systems for generating iPS cells. He shares insights on his work creating human models for neurodegenerative diseases, including Alzheimer’s and Parkinson’s. The conversation dives into the significance of automation in stem cell research, enhancing reproducibility and scaling. Scott also discusses his research goals, collaborations, and the future impact of stem cell innovations in clinical trials and personalized medicine.
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Automation Uncovers Genetic Signals
- Automated iPSC production reduces technician-to-technician variability and technical noise in large studies.
- Standardized workflows help genetic differences emerge over procedural artifacts.
Bank Fibroblasts And Batch Similar Samples
- Freeze multiple vials of fibroblasts per patient and record growth metrics to batch similar samples.
- Bin comparable fibroblast behaviors to improve parallel reprogramming performance.
Automate mRNA Reprogramming For Consistency
- Use modified synthetic mRNA reprogramming with automated liquid handlers to improve consistency and efficiency.
- Automating transfections gave more consistent reprogramming performance run-to-run.
