Iron Culture presented by MASS Ep 351 - New Research on Constrained Model and NSAIDs
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Oct 29, 2025 Discover the latest insights on the constrained energy expenditure model and its implications on fitness. The hosts dissect new research suggesting how physical activity impacts total energy expenditure and the potential metabolic ceilings. They explore the effects of NSAIDs on muscle growth, warning about the risks of regular use for athletes. Additionally, a fascinating discussion emerges on the varying structures of PhD programs worldwide, emphasizing the importance of research experiences over institutional prestige.
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Constraint Needs An Energetic Stressor
- Adaptive downregulation of energy expenditure requires a stressor like low energy availability or sustained extreme activity to manifest.
- Without an intake shortfall, added activity often increases expenditure linearly because no constraint is needed.
Include Intake When Testing Constraint
- Avoid over-interpreting a simple curved-versus-linear plot; include energy intake context when evaluating constraint evidence.
- Reframe the classic constrained figure to account for energy availability and avoid oversimplification.
Diclofenac Increased Hypertrophy, Not Strength
- A new 12-week trial found oral diclofenac increased training-induced muscle hypertrophy versus placebo but did not increase strength.
- The hypertrophy effect was paralleled by altered muscle mRNA expression, indicating molecular differences without strength gains.