Conversations with Tyler

Noubar Afeyan on the Permission to Leap

Jan 13, 2021
Noubar Afeyan, co-founder of Moderna and CEO of Flagship Pioneering, is a biomedical innovator and philanthropist. He shares insights on the 'paranoid optimism' that fuels his entrepreneurial spirit, shaped by his Armenian-American heritage. Afeyan discusses the rapid development of the COVID-19 vaccine and the balance of corporate responsibility in biotech. He also explores the future of gene editing, the importance of a diverse culture in innovation, and the impact of his classical pianist mother on his life. His reflections on ethical decision-making and the role of immigrants in shaping America are equally captivating.
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ADVICE

Improving Biomedical Funding

  • Biomedical funding should support "enabling research," focusing on areas with potential impact and creating conditions for future breakthroughs.
  • Embrace unreasonable propositions and people for extraordinary findings.
INSIGHT

Systematic Success

  • Systematic thinking is an advantage in achieving exceptional results, which are not inherently unpredictable.
  • Institutions like the Broad Institute succeed by embracing leaps and fostering a culture that encourages risk-taking.
ANECDOTE

Boston's Innovation Ecosystem

  • Boston's strength as an innovation hub comes from its combination of world-class institutions, immigrant culture, and a forward-looking mindset.
  • Its emergent ecosystem, a product of iterative cycles and events, is often underappreciated and difficult to reproduce.
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