Lift Free And Diet Hard with Andrew Coates #446 Dr Lauren Colenso-Semple - Wellness Peptides and Differences Between Men’s and Women’s Training
Dr Lauren Colenso-Semple is back to tackle a series of current trends, narratives, and pseudoscientific claims in fitness and wellness, including:
-Is there any quality human research on “wellness peptides”
-What are wellness peptides
-Why are they becoming more popular
-Is there any evidence to suggest that muscle building is any different for women than men
-Is there any evidence that birth control affects muscle growth
-Is there any difference in protein timing needs for muscle growth in women
-Are there notable differences in muscle fibre type between men and women
-Is there any association between testosterone levels and lean mass and strength in women
-Does menopause accelerate muscle loss
-Is creatine as potent as it’s currently hyped
-Is there any evidence to support cycle syncing
-Why is messaging around unique physiological differences so appealing to women
-Why are some fitness and wellness “professionals” incentivized to brand around differences in men’s and women’s training physiology
-Are there differences in injury risks across the phases of menstrual cycles
-Do vibration plates have any benefits
-Is calling out female creators for spreading misinformation by other women “mean girl behaviour”
-And much more
IG: @drlaurencs1
CHAPTERS
01:00 What Are Wellness Peptides and Why They’re Trending
02:00 How Peptides Work in the Body
03:00 Drug Development and Approval Process
04:00 Unapproved Peptides in the Wellness Market
07:00 Biological Risks and Tumor Concerns
08:00 Limited Human Data and Research Quality
09:00 Placebo Effects and Pain Resolution
10:00 Drug Approval vs Evidence Reality
11:00 Placebo Surgery Example and Mind-Body Effects
12:00 The “Wild West” of Peptide Research
13:00 Manufacturing and Dosing Risks
14:00 Why Peptides Became Popular
15:00 Normalization of Injectables and “Natural” Marketing
20:00 Branding Differences Between Approved Drugs and Peptides
24:00 Historical Drug Regulation Context
25:00 Are Muscle Gains Different Between Men and Women?
26:00 Molecular and Physiological Similarities Between Sexes
27:00 Muscle Fiber Type Complexity
30:00 Genetics vs Training Adaptation
33:00 Athlete Caliber vs Sex Differences
37:00 Creatine Performance Effects
38:00 Creatine and Clinical Populations
39:00 High Dose Creatine Considerations
42:00 Testosterone Myths and Hypertrophy
43:00 Menopause and Muscle Loss
45:00 Measuring Testosterone and Lab Variability
46:00 PCOS and Testosterone Levels
47:00 Research Gaps in PCOS and Performance
48:00 Menstrual Cycle Strength Research Discussion
51:00 Why Cycle Syncing Messaging Is Appealing
52:00 Marketing Incentives and Female Targeting
53:00 Diet Culture Parallel and Behavior Change
54:00 Individualization vs Simple Prescriptions
55:00 Age vs Training Factors That Actually Matter
58:00 Vibration Plates — Claims vs Evidence
59:00 Exercise vs Passive Modalities
01:01:00 Injury Risk Across Menstrual Cycle Phases
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