
LaBossiere Podcast #58 - Miles Grimshaw
30 snips
Sep 4, 2025 Miles Grimshaw, Partner at Thrive Capital, shares fascinating insights into the tech investment landscape. He discusses the transformative effect of AI on startups, emphasizing the importance of creativity and adaptability in innovation. Miles contrasts different investing approaches, likening them to physics and biology, and explores 'business genetics' in evaluating new ventures. He also highlights the power of incremental success in business strategy, drawing parallels to Amazon's growth, and underscores the significance of collaboration in achieving remarkable outcomes.
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How To Judge Early Company Genetics
- Evaluate early startups by authenticity, high ceiling, and strong business genetics.
- Project product indigestion, retention, and ecosystem potential to judge long‑term compounding.
When To Go Multi‑Product
- Delay multi‑product expansion until core momentum and orbit are secure.
- Build muscle for second‑acts early while the first product still has strong growth.
From Co‑Pilot To Command Center
- Applications win by shaping base models into 'can't‑unsee' command centers, not thin API wrappers.
- Fast, full‑stack teams that integrate intelligence into workflows achieve defensibility.




