Professor Joanna Moncrieff on chemical imbalance and the serotonin theory of depression

Welcome to episode 200 with Professor Joanna Moncrieff who is a psychiatrist, author and researcher who is one of the founding members of the Critical Psychiatry Network.

In 2022, Joanna was the lead author of a study that explored the ‘chemical imbalance’ theory of depression and found that no clear evidence that serotonin levels or serotonin activity are responsible for depression.

The study became one of the 400 most shared of the 21 million papers that have ever been tracked and caused great debate throughout the mental health space.

In this episode I chat to Joanna about this research, what it involved and what the findings showed.

We chat about some of the response and criticism to this piece of work and how the chemical imbalance theory came to prominence in the first place.

We talk about some of the other’s factors that could be causing depression if it isn’t in fact serotonin as the research shows.

We also chat about depression, serotonin, anti-depressants, diagnosis and labels and what the future of mental health treatment and support could look like.

Medication is a very personal choice and the aim of this episode isn’t to debate or influence anyone on their views on anti-depressants, just simply to explore this aspect of the mental health conversation because I think that’s important.

Don’t make decisions about your own medication without discussing it with a medical professional.

You can find the original study here: The serotonin theory of depression: a systematic umbrella review of the evidence | Molecular Psychiatry

A summary of some of the responses and criticism here:  expert reaction to a review paper on the ‘serotonin theory of depression’ | Science Media Centre

And a response from Joanna to that specific criticism here:  Response to Criticism of Our Serotonin Paper - Mad In America

Joanna’s new book is called Chemically Imbalanced: the making and unmaking of the serotonin myth and it’s out now.

There is loads more information about Joanna’s work at her website https://joannamoncrieff.com

You can connect with me on social media @propermentalpodcast or via www.propermentalpodcast.com.

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Thanks for listening!