Physionic A Deep Dive on NAD+ and Longevity, Ft. Rimon from Wellness Messiah
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Nov 2, 2024 Dive into the fascinating world of NAD+, a molecule critical for energy production and longevity. Discover the latest in NAD+ boosting strategies, supplements like NMN and niacinamide, and their effects on aging. The conversation also unpacks the intriguing connection between diet, exercise, and NAD+ levels, with insights into gender-specific responses. Unpublished studies reveal groundbreaking findings on improving NAD+ in humans, while discussing the broader implications of research on aging and health autonomy. Don't miss out on personalized strategies for optimizing your health!
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NAD Powers Epigenetic Control And DNA Repair
- NAD fuels sirtuins and PARP enzymes that control epigenetic regulation and DNA repair, linking NAD to aging mechanisms.
- Rimon explains NAD acts as 'food' for these enzymes, so NAD availability affects gene activation timing and DNA damage repair.
Sinclair's Information Theory Reframes Aging
- Dr. Sinclair reframed aging as loss of epigenetic information rather than accumulated genetic damage, shifting focus to how genes are used over time.
- Rimon highlights that cells 'lose identity' with age as the epigenome misregulates which genes are on or off.
DNA Repair Steals NAD From Epigenetic Maintenance
- PARP-mediated DNA repair competes with sirtuins for NAD, so when DNA damage is high NAD is diverted to repair at the expense of epigenetic maintenance.
- Rimon frames this as DNA prioritizing integrity for future generations over current epigenetic preservation.