CoinDesk Podcast Network Charles Hoskinson on Cardano’s Greatest Challenge, Why Ethereum Will Fail and His $200M Bet on American Healthcare | CoinDesk Spotlight
Sep 9, 2025
Charles Hoskinson, CEO and co-founder of Input Output and a key figure in Ethereum and Cardano, dives into the future of crypto. He boldly claims Ethereum may not survive the next decade and reveals Bitcoin DeFi as a 'sleeping giant.' The conversation shifts to his ambitious investments aimed at transforming American healthcare and even de-extincting species through synthetic biology. Hoskinson emphasizes the need for patient-centered solutions and discusses the disruptive potential of tech in both the crypto and healthcare sectors.
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Shared-State VMs Face Obsolescence
- Hoskinson argues shared-state L1 VMs may lose relevance as ZK proofs and off-chain computation mature.
- Big tech and TradFi can be 'Ethereum adjacent' without strong incentives to rebuild on-chain.
Design Privacy With Selective Disclosure
- Build selective-disclosure and zero-knowledge systems to satisfy compliance without sacrificing privacy.
- Use algorithmic proofs to prove attributes (age, accreditation) without revealing full identity.
The Sleeping Giant: Bitcoin DeFi
- Bitcoin DeFi could attract hundreds of billions in TVL if built to satisfy maximalist principles.
- Security from Bitcoin, fees paid in Bitcoin, and returns in Bitcoin will win Bitcoin-first users.