The Cribsiders S7 Ep173: Neuromuscular Bouquet (FFTC)
Apr 8, 2026
Rapid-fire review of muscular dystrophy signs, CK testing, and genetic and gene therapy approaches. Practical discussion of dystrophin biology, steroid regimens, and respiratory and cardiac management. Concise coverage of cerebral palsy definitions, early signs, imaging, and spasticity treatments. Clear guidance on trisomy 21 newborn screening, comorbidities, and transition to adult care.
AI Snips
Chapters
Books
Transcript
Episode notes
CP Is A Pattern Not A Single Cause
- Cerebral palsy (CP) is a non-progressive movement/posture disorder from brain injury before age two, not a single etiologic diagnosis.
- Prematurity is the most common risk factor, but CP has many prenatal and early-life causes.
Refer Early And Start Services Before Formal CP Diagnosis
- Refer early to PT/OT and neurology/PM&R when milestones are off; start birth-to-three services without waiting for a formal CP diagnosis.
- Use MRI without contrast for initial evaluation but know 5–15% of CP cases have a normal MRI.
Manage Spasticity With Baclofen Then Escalate Carefully
- Treat spasticity first-line with oral baclofen (start 0.5 mg/kg/day divided TID, titrate up) and consider benzodiazepines when appropriate.
- For refractory spasticity consider intrathecal baclofen pump but monitor for dangerous withdrawal.
