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LDL As Adaptive Repair Not Primary Toxin
- LDL is likely an adaptive delivery and repair particle rather than the root cause of atherosclerosis.
- Paul Saladino argues LDL's presence in plaques could reflect repair of endothelial damage driven by other factors, not direct LDL toxicity.
Remember Cholesterol Is Essential Before Lowering It
- Recognize cholesterol is essential: it's the steroid backbone for hormones and cell membranes, so don't reflexively suppress its production.
- Saladino warns statins inhibit HMG-CoA reductase and reduce downstream molecules like coenzyme Q10 and steroid hormones.
Homeoviscous Model Explains LDL Rise On Saturated Fat
- The homeoviscous adaptation model explains why saturated fat raises LDL: membranes enriched in saturated fat need more cholesterol to maintain fluidity.
- Saladino cites the 2021 American Journal of Clinical Nutrition paper arguing LDL rises may be normal adaptive responses to dietary fat composition.