#253 - What is insulin resistance and why does it matter? | Dr. Rob Lustig & Dr. Dominic D’Agostino - (Replay)

Insulin resistance is when cells stop responding to insulin’s signal to uptake glucose. It’s a hallmark of prediabetes, Type 2 diabetes, and other forms of metabolic dysfunction, and it manifests as several chronic disease, ranging from Alzheimer’s to polycystic ovarian syndrome. Dr. Rob Lustig and Dr. Dominic D’Agostino discuss the importance of monitoring insulin levels, why a high or increasing insulin level is a problem, and how insulin resistance hinders weight management.

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🎙 What Rob Lustig, MD, & Dr. Dominic D’Agostino, PhD, discuss:

(00:00) — Intro

(01:44) — What is insulin?

(04:43) — What is insulin resistance?

(15:50) — There are three types of insulin resistance

(36:03) — Weight management is not about calories in and calories out

(44:00) — Adding more insulin to the equation of Type 2 diabetes isn’t necessarily the answer

(49:31) — Insulin is a crucial biomarker to measure for metabolic health

(52:11) — Insulin resistance is a hindrance to weight management

(54:42) — The intake of too much leucine can lead to insulin resistance

(1:00:22) — Fiber feeds the gut microbiome and is crucial for metabolic health

(1:11:27) — Is intermittent fasting necessary?

⁠Transcripts & Show notes⁠

🔗 Helpful links:

Watch the conversation: ⁠https://youtu.be/dFOaBrujDHo⁠