Short Wave Mighty Mice Return From Space
Jan 21, 2020
NPR science correspondent Jon Hamilton dives into the fascinating world of 'mighty mice'—genetically modified creatures with quadrupled muscle mass, recently returned from a month in zero gravity. He shares insights from researchers who hope these findings could lead to breakthroughs in treating muscle and bone diseases in humans, especially for astronauts. The discussion also touches on the personal connection between two biochemists whose love story intertwines with their scientific journey, adding a heartfelt touch to the groundbreaking research.
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Mighty Mouse Encounter
- Jon Hamilton visited Se-Jin Lee's lab in 2006 and saw a mighty mouse.
- This mouse had four times the muscle mass of a normal mouse, resembling Arnold Schwarzenegger.
Myostatin's Role
- Scientists discovered a protein called myostatin, produced by muscle cells, which limits muscle fiber formation and growth.
- By removing the gene responsible for this protein, they created mice with significantly increased muscle mass.
Human Implications
- Myostatin-blocking drugs could potentially treat muscle-wasting diseases like muscular dystrophy.
- Though human trials haven't replicated the mice results, if successful, these drugs could revolutionize treatment.