The Rich Roll Podcast Does The Microbiome Hold The Key To Treating Parkinson’s, Autism & Other Diseases? CalTech Microbiologist Dr. Sarkis Mazmazian on The Gut-Brain Axis
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May 9, 2024 
This week’s guest, Dr. Sarkis Mazmanian, is a microbiologist and professor at Caltech, specializing in the gut-brain axis. He discusses how gut microbes influence neurological health, linking them to conditions like Parkinson's and autism. The conversation dives into the malleability of the adult microbiome and the potential for microbiome-based therapeutics. Dr. Mazmanian highlights challenges in translating animal research to humans and the gut’s role in shaping behaviors and cravings, emphasizing the importance of a healthy gut diet.
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Microbiome and Autism
- The gut microbiome can influence neurodevelopment, impacting conditions like autism.
- A specific molecule, 4-EPS, produced by gut bacteria, has been linked to anxiety-like behavior in mice.
Gut Microbiome's Impact
- The gut microbiome impacts the immune and nervous systems.
- It influences neurodevelopment and neurodegeneration, impacting conditions like Parkinson's and autism.
Microbiome Definition
- The microbiome comprises all organisms living in or on us.
- Most reside in the GI tract, but microbes inhabit all exposed surfaces except deep lung alveoli.