The Curious Clinicians 76 - Radical Regeneration
Sep 6, 2023
Learn about the liver's incredible regenerative ability after injury or resection. From ancient mythology to modern medicine, explore the concept of liver regeneration. Discover the two types of liver regeneration: resection and cellular injury. Uncover the triggers and mechanisms of liver regeneration including hemodynamic changes, the immune response, and platelets. Delve into the signals that control liver regeneration, including growth factors and our body's mechanisms.
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Prometheus' Liver: Ancient Knowledge?
- The ancient Greek myth of Prometheus, whose liver regenerated daily after being eaten by an eagle, might reflect early knowledge of this ability.
- Some scholars debate whether it represents true anatomical knowledge or symbolic meaning related to the soul.
Modern Confirmation of Liver Regeneration
- Modern medicine confirmed liver regeneration in 1879 with H. Tillmanns' rabbit experiments.
- While kidneys scarred, livers regrew quickly after resection, showcasing vibrant new tissue.
Human Liver Regeneration: Living Proof
- Human liver regeneration is evident in living donor transplants.
- Both the donor's remaining liver and the transplanted portion regenerate to full size within weeks, even after resecting up to 80%.