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Causal Brain Network For Tics
- Ganos and colleagues identified a reproducible brain network causally linked to tics involving insula, striatum, thalamus, and cerebellum.
- This network offers a blueprint for understanding tic pathophysiology and targeting interventions.
Functional Roles Within The Tic Network
- The insula links interoceptive experience to tic generation while striatum assigns salience to behaviors.
- Thalamus and cerebellum contribute outflow and motor fine-tuning within the tic network.
Explore Neuromodulation Targeting Network Nodes
- Targeting identified network nodes with neuromodulation could improve tic symptoms in future studies.
- Researchers should explore deep brain stimulation and other neuromodulatory methods in larger trials.