Becker’s Healthcare Podcast From Joint Replacement to Proactive Longevity with Grant Zarzour, MD
Mar 15, 2026
Grant Zarzour, MD, an orthopedic surgeon and founder/CEO of Sperity Health focused on proactive longevity. He recounts a personal family health journey that shaped his data-driven approach. He discusses measuring biological age, using wearables and CGMs, and building interventions like nutrition, VO2 testing, and emotional activation. He also explains how data motivates behavior change and Sperity’s in-person delivery model.
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Turning A Family Crisis Into A Proactive Health Journey
- Grant Zarzour used his son Wyatt’s autism diagnosis to discover proactive, nonpharmacologic interventions that dramatically improved outcomes.
- Over eight years Wyatt moved from moderate autism and potential lifelong meds to barely detectable autism and an IQ of 141 through diet, sleep, therapy, and supplements.
A Single Christmas Blessing Marked Major Progress
- A breakthrough moment came when Wyatt independently asked to say a blessing at Christmas, signaling major progress.
- This emotional milestone convinced Zarzour that proactive interventions had fundamentally changed his son's trajectory.
Biological Age Beats Chronological Age For Risk
- Biological age matters more than chronological age for clinical decisions and longevity predictions.
- Sperity measures a biological age from 10 lab values to determine organ health and guide interventions like surgery candidacy or preventive care.