The Science Behind Genetically-Optimized Performance Protocols #393

Sep 29, 2025

In this engaging discussion, Sam and Alex from Fitness Genes explore how genetic insights can revolutionize fitness and health. Sam, a CEO with a background in evolutionary biology, reveals how DNA plays a critical role in muscle growth, recovery, and even health risks like cholesterol. Alex, the science lead, dives into the implications of genetic variants, detailing how personalized training protocols stem from an understanding of our DNA. They also uncover surprising insights, like how your genetics can predict your stress response and dietary needs.

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ANECDOTE

Family Cholesterol Reversal Story

Sam used family genetics to identify elevated cholesterol risk and prescribed specific foods and supplements.
Within three months their LDL dropped 17–24% using targeted dietary changes and psyllium, garlic and oat bran.

INSIGHT

Single-Gene Versus Polygenic Risks

Some conditions are single-gene and high-impact while others are polygenic and probabilistic.
Fitness Genes uses both single-gene flags and polygenic risk scores to triage health priorities.

INSIGHT

ACTN3 Explains Power And Recovery

ACTN3 (alpha-actinin-3) links strongly to power performance and muscle recovery differences.
Lack of the protein increases muscle damage risk and necessitates longer recovery and targeted supplementation like creatine.

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Whenever you're ready... here are 3 ways we can help you look, feel and perform at your best: 1. Grab a free copy of 1 of our BRAND NEW Peak Performance Protocols. This is for high performers looking to 10x their training and nutrition results by becoming 10x more effective. Click here - https://go.muscleintelligence.com/high-performance-executive-report/ 2. Join the Muscle Intelligence Community and connect with other men like you who want to uplevel their health and fitness. It's our new Facebook group where I coach members live, share what's working with my private clients and announce tickets to my upcoming trainings and events. Click here - https://www.muscleintelligence.com/community 3. Work with me 1-on-1 If you're a top performing executive or entrepreneur who wants a fully customized comprehensive health protocol and support from a team of world-class specialists, click here to speak with a member of my team to review all of your goals and options: https://www.muscleintelligence.com/apply?utm_campaign=YT Episode Details: Genetics might be the missing link in your training, recovery, and long-term health. In this episode, Ben sits down with Sam and Alex from Fitness Genes to unpack how DNA testing is transforming the way we approach fitness and longevity. They reveal how your genes influence muscle growth, recovery, sleep patterns, stress response, and even hidden health risks like cholesterol or Alzheimer's. If you've ever wondered why two people can follow the same plan and get completely different results, this conversation will give you the clarity and confidence to build a blueprint that actually works for your body. 5 Bullet Points:

Genetics as the missing link in performance planning
How DNA shapes recovery, muscle growth, and energy
Real-life examples of genetic testing changing lives
The link between genes and disease prevention
How to build a personalized blueprint for training

Connect with Our Guests Genetically Optimise Your Health & Fitness https://www.fitnessgenes.com/ Social Media @fitnessgenes @samdecombel About Ben Ben Pakulski is the Chief Performance Officer to elite executives, successful entrepreneurs, and top athletes.With over 25 years of experience, he coaches high achievers to build the physical, psychological, and metabolic resilience required to lead at the highest level. As the creator of the Muscle Intelligence framework, Ben specializes in aligning biology and behavior to drive sustained peak performance. His mission is to redefine what's possible for people in their prime and push the boundaries of human potential.