FoundMyFitness #109 How To Boost NAD Levels To Fight Inflammation, Improve Recovery, and Slow Aging | Dr. Charles Brenner
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Feb 9, 2026 
Dr. Charles Brenner, biochemist who discovered nicotinamide riboside and studies NAD biology. He discusses why tissue NAD falls with age and illness. He walks through how infection, obesity, sleep disruption, and circadian timing affect NAD. He clarifies which NAD precursors, delivery methods, and timing actually raise NAD and who might benefit from supplementation.
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Blood NAD Can Be Misleading
- Blood NAD often stays normal with age but tissue NAD (brain, liver, muscle) can decline and be disturbed.
- Therefore blood NAD measurements can miss important tissue-specific NAD deficits.
Infection Activates PARPs And Drains NAD
- Viral infections (e.g., coronavirus) transcriptionally activate multiple PARP enzymes that consume NAD.
- This innate immune response can substantially drain NAD during infection.
Use NR To Lower Chronic Inflammation
- Consider nicotinamide riboside (NR) at 500–1000 mg/day to lower inflammation in people with elevated inflammatory status.
- Multiple randomized trials show NR reduces IL-6 and other inflammatory markers.